MSc Defence: A Combined Ode Model of Carbohydrate Fermentation and Colorectal Cancer (Alexandra (Lexy) Lawryshyn)
CANDIDATE: Alexandra (Lexy) Lawryshyn
ABSTRACT:
We formulate and analyze a system of non-linear ordinary differential equations that describe key metabolic and immunological interactions between butyrate produced by fiber- fermenting gut microbiota, colorectal cancer cells and host cell populations. The model is studied both independently and in conjunction with a pre-existing carbohydrate fermentation model. The parameter space is explored through steady-state and sensitivity analyses. Simulation experiments are conducted to illustrate the...